Analysis performed on 2024-09-30 10:20:23
| Initial | Filtered Out | Final | Blast | |
|---|---|---|---|---|
| Bacteria | 42867 | 603 | 42264 | 26267 |
| Archaea | 2984 | 55 | 2929 | 1390 |
| Vertebrata | 1376 | 395 | 981 | 415 |
| Mammals | 985 | 121 | 864 | 134 |
| Protein Length | Pathogenic Variants | Benign/Unknown Variants |
|---|---|---|
| 509 | 30 | 460 |
| Domains | |
|---|---|
| Current Study | 1, 50 |
| Guo et al (2010) | 3, 43 |
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 460 | 49 | 509 | 9.387755 |
| Number of Variants | 437 | 53 | 490 | 8.245283 |
| Number of Pathogenic Variants | 29 | 1 | 30 | 29.000000 |
| Number of Benign/Unknown Variants | 408 | 52 | 460 | 7.846154 |
| Fisher exact test | 0.233066 |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 468 | 41 | 509 | 11.414634 |
| Number of Variants | 445 | 45 | 490 | 9.888889 |
| Number of Pathogenic Variants | 29 | 1 | 30 | 29.000000 |
| Number of Benign/Unknown Variants | 416 | 44 | 460 | 9.454545 |
| Fisher exact test | 0.507492 |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| # of sites Ancient | # sites Modern | Mean Ancient (SD) | Mean Modern (SD) | Median Ancient | Median Modern | Mann-Whitney U | p-value | |
|---|---|---|---|---|---|---|---|---|
| Current Study | 460 | 49 | 0.90 (0.01) | 0.74 (0.02) | 9.628e-01 | 7.432e-01 | 17929.00 | 5.11e-12 |
| Guo et al (2010) | 468 | 41 | 0.90 (0.01) | 0.73 (0.03) | 9.602e-01 | 7.293e-01 | 15441.00 | 4.76e-11 |
The Mann-Whitney U test was calculated using the conservation scores of the amino acids in ancient and modern domains. The p-value is for the null hypothesis that the conservation scores in ancient domains are greater than in modern domains.